calcium sulfate loaded antibiotics  (Biocomposites Inc)

Journal: Cureus

Article Title: Proximal Femoral Replacement for Infected Non-union of the Proximal Femur With Adherent Femoral Artery: Surgical Challenges and Techniques to Minimize Vascular Risk

doi: 10.7759/cureus.107733

Figure Lengend Snippet: An anteroposterior pelvis radiograph taken on the same day of surgery demonstrating a right-sided cemented DePuy Synthes modular proximal femoral replacement with an uncemented DePuy Synthes Pinnacle acetabular cup and constrained liner. The femoral stem is well-seated within the cement mantle, and multiple screws secure the acetabular reconstruction cage. The greater trochanter was preserved and reattached through the prosthesis to restore abductor integrity. Prophylactic cerclage wiring was applied around the bone-implant interface for additional construct stability. Antibiotic-loaded STIMULAN beads are visible around the implant site. The right hip joint remains native and intact.

Article Snippet: The femoral stem was cemented, and antibiotic-loaded calcium sulfate (STIMULAN, Biocomposites Ltd., Staffordshire, UK) beads were placed around the implant.

Techniques: Construct

Journal: Antibiotics

Article Title: Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model

doi: 10.3390/antibiotics10030270

Figure Lengend Snippet: ( A ). LCMS analysis of vancomycin in effluent samples from antibiotic loaded calcium sulfate beads with an antibiotic loaded PMMA spacer (CSB v+t plusSpacer v+t ), antibiotic loaded PMMA spacer (Spacer v+t ), and vancomycin powder bolus (VP). N = 9; geometric mean ±SE. The yellow curve is the influent saline flow rate. Time is shown on a log2 scale to more clearly show the changes in concentration at the early time points. ( B ). Log difference of vancomycin effluent concentrations of the CSB v+t plusSpacer v+t compared to the Spacer v+t alone. (* p < 0.05, ** p < 0.01).

Article Snippet: Antibiotic loaded calcium sulfate beads (CSB v+t ) of size 4.8 mm were prepared using Stimulan ® Rapid Cure (SRC) (Biocomposites Ltd., Staffordshire, UK) 10-cc mixing kits.

Techniques: Saline, Concentration Assay

Journal: Antibiotics

Article Title: Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model

doi: 10.3390/antibiotics10030270

Figure Lengend Snippet: ( A ). LCMS analysis of tobramycin in effluent samples from antibiotic loaded calcium sulfate beads with an antibiotic loaded PMMA spacer (CSB v+t plusSpacer v+t ), and antibiotic loaded PMMA spacer (Spacer v+t ). N = 6; geometric mean ± SE. The yellow curve is the influent saline flow rate. Time is shown on a log2 scale to show the changes more clearly in concentration at the early time points. ( B ). Log difference of tobramycin concentrations of the CSB v+t plusSpacer v+t method compared to the Spacer v+t method. (* p < 0.05).

Article Snippet: Antibiotic loaded calcium sulfate beads (CSB v+t ) of size 4.8 mm were prepared using Stimulan ® Rapid Cure (SRC) (Biocomposites Ltd., Staffordshire, UK) 10-cc mixing kits.

Techniques: Saline, Concentration Assay

Journal: Antibiotics

Article Title: Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model

doi: 10.3390/antibiotics10030270

Figure Lengend Snippet: Tobramycin and vancomycin exposure via antibiotic administration methods to the system at 2, 12, 24 and 48 h. N = 4 replicates for Spacerv+t and CSBv+tplusSpacerv+t and 3 for VP; geometric mean ± 1 SE. (* p < 0.05, ** p < 0.01, *** p < 0.001). The same data shown on a linear Y-axis scale are available in .

Article Snippet: Antibiotic loaded calcium sulfate beads (CSB v+t ) of size 4.8 mm were prepared using Stimulan ® Rapid Cure (SRC) (Biocomposites Ltd., Staffordshire, UK) 10-cc mixing kits.

Techniques: